A statin-dependent QTL for GATM expression is associated with statin-induced myopathy
A statin-dependent QTL for GATM expression is associated with statin-induced myopathy
About this item
Full title
Author / Creator
Mangravite, Lara M. , Engelhardt, Barbara E. , Medina, Marisa W. , Smith, Joshua D. , Brown, Christopher D. , Chasman, Daniel I. , Mecham, Brigham H. , Howie, Bryan , Shim, Heejung , Naidoo, Devesh , Feng, QiPing , Rieder, Mark J. , Chen, Yii.-Der I. , Rotter, Jerome I. , Ridker, Paul M. , Hopewell, Jemma C. , Parish, Sarah , Armitage, Jane , Collins, Rory , Wilke, Russell A. , Nickerson, Deborah A. , Stephens, Matthew and Krauss, Ronald M.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Exploration of the interacting effect of statin exposure and genetic variation on gene expression identifies a
cis-
eQTL that is differentially associated with expression of the
GATM
gene, which encodes a rate-limiting enzyme involved in creatine synthesis, and that is associated with incidence of statin-induced myopathy, the major adv...
Alternative Titles
Full title
A statin-dependent QTL for GATM expression is associated with statin-induced myopathy
Authors, Artists and Contributors
Author / Creator
Engelhardt, Barbara E.
Medina, Marisa W.
Smith, Joshua D.
Brown, Christopher D.
Chasman, Daniel I.
Mecham, Brigham H.
Howie, Bryan
Shim, Heejung
Naidoo, Devesh
Feng, QiPing
Rieder, Mark J.
Chen, Yii.-Der I.
Rotter, Jerome I.
Ridker, Paul M.
Hopewell, Jemma C.
Parish, Sarah
Armitage, Jane
Collins, Rory
Wilke, Russell A.
Nickerson, Deborah A.
Stephens, Matthew
Krauss, Ronald M.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3933266
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3933266
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/nature12508
