Targeting ER stress–induced autophagy overcomes BRAF inhibitor resistance in melanoma
Targeting ER stress–induced autophagy overcomes BRAF inhibitor resistance in melanoma
About this item
Full title
Author / Creator
Ma, Xiao-Hong , Piao, Sheng-Fu , Dey, Souvik , Mcafee, Quentin , Karakousis, Giorgos , Villanueva, Jessie , Hart, Lori S. , Levi, Samuel , Hu, Janice , Zhang, Gao , Lazova, Rossitza , Klump, Vincent , Pawelek, John M. , Xu, Xiaowei , Xu, Wei , Schuchter, Lynn M. , Davies, Michael A. , Herlyn, Meenhard , Winkler, Jeffrey , Koumenis, Constantinos and Amaravadi, Ravi K.
Publisher
United States: American Society for Clinical Investigation
Journal title
Language
English
Formats
Publication information
Publisher
United States: American Society for Clinical Investigation
Subjects
More information
Scope and Contents
Contents
Melanomas that result from mutations in the gene encoding BRAF often become resistant to BRAF inhibition (BRAFi), with multiple mechanisms contributing to resistance. While therapy-induced autophagy promotes resistance to a number of therapies, especially those that target PI3K/mTOR signaling, its role as an adaptive resistance mechanism to BRAFi i...
Alternative Titles
Full title
Targeting ER stress–induced autophagy overcomes BRAF inhibitor resistance in melanoma
Authors, Artists and Contributors
Author / Creator
Piao, Sheng-Fu
Dey, Souvik
Mcafee, Quentin
Karakousis, Giorgos
Villanueva, Jessie
Hart, Lori S.
Levi, Samuel
Hu, Janice
Zhang, Gao
Lazova, Rossitza
Klump, Vincent
Pawelek, John M.
Xu, Xiaowei
Xu, Wei
Schuchter, Lynn M.
Davies, Michael A.
Herlyn, Meenhard
Winkler, Jeffrey
Koumenis, Constantinos
Amaravadi, Ravi K.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3934165
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3934165
Other Identifiers
ISSN
0021-9738
E-ISSN
1558-8238
DOI
10.1172/JCI70454
