BACH2 mediates negative selection and p53-dependent tumor suppression at the pre-B cell receptor che...
BACH2 mediates negative selection and p53-dependent tumor suppression at the pre-B cell receptor checkpoint
About this item
Full title
Author / Creator
Swaminathan, Srividya , Huang, Chuanxin , Geng, Huimin , Chen, Zhengshan , Harvey, Richard , Kang, Huining , Ng, Carina , Titz, Björn , Hurtz, Christian , Sadiyah, Mohammed Firas , Nowak, Daniel , Thoennissen, Gabriela B , Rand, Vikki , Graeber, Thomas G , Koeffler, H Phillip , Carroll, William L , Willman, Cheryl L , Hall, Andrew G , Igarashi, Kazuhiko , Melnick, Ari and Müschen, Markus
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Nature Publishing Group US
Subjects
More information
Scope and Contents
Contents
During B cell development, cells that fail to productively rearrange their immunoglobulin VH-DJH gene segments to generate an in-frame junction that codes for a functional pre-B cell receptor are deleted. Markus Müschen and colleagues now report that Bach2 is a key component of this pre-B cell receptor checkpoint that enables the elimination of nor...
Alternative Titles
Full title
BACH2 mediates negative selection and p53-dependent tumor suppression at the pre-B cell receptor checkpoint
Authors, Artists and Contributors
Author / Creator
Huang, Chuanxin
Geng, Huimin
Chen, Zhengshan
Harvey, Richard
Kang, Huining
Ng, Carina
Titz, Björn
Hurtz, Christian
Sadiyah, Mohammed Firas
Nowak, Daniel
Thoennissen, Gabriela B
Rand, Vikki
Graeber, Thomas G
Koeffler, H Phillip
Carroll, William L
Willman, Cheryl L
Hall, Andrew G
Igarashi, Kazuhiko
Melnick, Ari
Müschen, Markus
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3954721
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3954721
Other Identifiers
ISSN
1078-8956
E-ISSN
1546-170X
DOI
10.1038/nm.3247
