CBR antimicrobials alter coupling between the bridge helix and the β subunit in RNA polymerase
CBR antimicrobials alter coupling between the bridge helix and the β subunit in RNA polymerase
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Contents
Bacterial RNA polymerase (RNAP) is a validated target for antibacterial drugs. CBR703 series antimicrobials allosterically inhibit transcription by binding to a conserved α helix (β′ bridge helix, BH) that interconnects the two largest RNAP subunits. Here we show that disruption of the BH-β subunit contacts by amino-acid substitutions invariably re...
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Full title
CBR antimicrobials alter coupling between the bridge helix and the β subunit in RNA polymerase
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3959191
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3959191
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/ncomms4408
