Atomic View of a Toxic Amyloid Small Oligomer
Atomic View of a Toxic Amyloid Small Oligomer
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Author / Creator
Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS) , Laganowsky, Arthur , Liu, Cong , Sawaya, Michael R. , Whitelegge, Julian P. , Park, Jiyong , Zhao, Minglei , Pensalfini, Anna , Soriaga, Angela B. , Landau, Meytal , Teng, Poh K. , Cascio, Duilio , Glabe, Charles and Eisenberg, David
Publisher
Washington, DC: American Association for the Advancement of Science
Journal title
Language
English
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Publisher
Washington, DC: American Association for the Advancement of Science
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Scope and Contents
Contents
Amyloid diseases, including Alzheimer's, Parkinson's, and the priori conditions, are each associated with a particular protein in fibrillar form. These amyloid fibrils were long suspected to be the disease agents, but evidence suggests that smaller, often transient and polymorphic oligomers are the toxic entities. Here, we identify a segment of the...
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Full title
Atomic View of a Toxic Amyloid Small Oligomer
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3959867
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3959867
Other Identifiers
ISSN
0036-8075
E-ISSN
1095-9203
DOI
10.1126/science.1213151
