Sequence-based design of bioactive small molecules that target precursor microRNAs
Sequence-based design of bioactive small molecules that target precursor microRNAs
About this item
Full title
Author / Creator
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Nature Publishing Group US
Subjects
More information
Scope and Contents
Contents
Oligonucleotide-based RNA targeting is facilitated by base pairing rules, but identifying small molecules that uniquely bind a specific RNA sequence has been challenging. Inforna, an RNA sequence–based lead optimization strategy, was developed and applied to identify small molecules that inhibit pre-microRNA processing.
Oligonucleotides are desi...
Alternative Titles
Full title
Sequence-based design of bioactive small molecules that target precursor microRNAs
Authors, Artists and Contributors
Author / Creator
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3962094
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3962094
Other Identifiers
ISSN
1552-4450
E-ISSN
1552-4469
DOI
10.1038/nchembio.1452
