Activation and characterization of a cryptic polycyclic tetramate macrolactam biosynthetic gene clus...
Activation and characterization of a cryptic polycyclic tetramate macrolactam biosynthetic gene cluster
About this item
Full title
Author / Creator
Luo, Yunzi , Huang, Hua , Liang, Jing , Wang, Meng , Lu, Lu , Shao, Zengyi , Cobb, Ryan E. and Zhao, Huimin
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Polycyclic tetramate macrolactams (PTMs) are a widely distributed class of natural products with important biological activities. However, many of these PTMs have not been characterized. Here we apply a plug-and-play synthetic biology strategy to activate a cryptic PTM biosynthetic gene cluster SGR810-815 from
Streptomyces griseus
and discove...
Alternative Titles
Full title
Activation and characterization of a cryptic polycyclic tetramate macrolactam biosynthetic gene cluster
Authors, Artists and Contributors
Author / Creator
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Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3969335
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3969335
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/ncomms3894
