Pharmacological inhibition of poly(ADP-ribose) polymerase-1 modulates resistance of human glioblasto...
Pharmacological inhibition of poly(ADP-ribose) polymerase-1 modulates resistance of human glioblastoma stem cells to temozolomide
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Publisher
England: BioMed Central
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English
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England: BioMed Central
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Chemoresistance of glioblastoma multiforme (GBM) has been attributed to the presence within the tumor of cancer stem cells (GSCs). The standard therapy for GBM consists of surgery followed by radiotherapy and the chemotherapeutic agent temozolomide (TMZ). However, TMZ efficacy is limited by O6-methylguanine-DNA-methyltransferase (MGMT) and Mismatch...
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Pharmacological inhibition of poly(ADP-ribose) polymerase-1 modulates resistance of human glioblastoma stem cells to temozolomide
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3975727
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3975727
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ISSN
1471-2407
E-ISSN
1471-2407
DOI
10.1186/1471-2407-14-151
