Isthmin targets cell-surface GRP78 and triggers apoptosis via induction of mitochondrial dysfunction
Isthmin targets cell-surface GRP78 and triggers apoptosis via induction of mitochondrial dysfunction
About this item
Full title
Author / Creator
Chen, M , Zhang, Y , Yu, V C , Chong, Y-S , Yoshioka, T and Ge, R
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Isthmin (ISM) is a secreted 60-kDa protein that potently induces endothelial cell (EC) apoptosis. It suppresses tumor growth and angiogenesis in mice when stably overexpressed in cancer cells. Although
α
v
β
5 integrin serves as a low-affinity receptor for ISM, the mechanism by which ISM mediates antiangiogenesis and apoptosis in ECs re...
Alternative Titles
Full title
Isthmin targets cell-surface GRP78 and triggers apoptosis via induction of mitochondrial dysfunction
Authors, Artists and Contributors
Author / Creator
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3978310
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3978310
Other Identifiers
ISSN
1350-9047
E-ISSN
1476-5403
DOI
10.1038/cdd.2014.3
