Adoptive immunotherapy with engineered T cells expressing and HLA-A2 restricted affinity-enhanced TC...
Adoptive immunotherapy with engineered T cells expressing and HLA-A2 restricted affinity-enhanced TCR for LAGE-1 and NY-ESO-1 in patients with multiple myeloma following auto-SCT
About this item
Full title
Author / Creator
Rapoport, Aaron P , Stadtmauer, Edward A , Vogl, Dan T , Weiss, Brendan , Binder-Scholl, Gwendolyn K , Smethurst, Dominic P , Finklestein, Jeffrey , Kulikovskaya, Irina , Gupta, Minnal , Brewer, Joanna E , Bennett, Alan D , Gerry, Andrew B , Pumphrey, Nick J , Tayton-Martin, Helen K , Ribeiro, Lilliam , Badros, Ashraf Z , Yanovich, Saul , Akpek, Gorgun , Kerr, Naseem , Philip, Sunita , Westphal, Sandra , Bruce, Levine L , Jakobsen, Bent K , June, Carl H and Kalos, Michael
Publisher
London: BMJ Publishing Group LTD
Journal title
Language
English
Formats
Publication information
Publisher
London: BMJ Publishing Group LTD
Subjects
More information
Scope and Contents
Contents
We report on a 26 patient phase I/II clinical trial (NCT01352286) to investigate the safety, feasibility and anti-tumor activity of T cells engineered to express an affinity-enhanced TCR that recognizes the NY-ESO-1/LAGE-1 peptide complex HLA-A*0201-SLLMWITQC. Patients with high risk or relapsed, NYESO-1 and/or LAGE-1 positive multiple myeloma (MM)...
Alternative Titles
Full title
Adoptive immunotherapy with engineered T cells expressing and HLA-A2 restricted affinity-enhanced TCR for LAGE-1 and NY-ESO-1 in patients with multiple myeloma following auto-SCT
Authors, Artists and Contributors
Author / Creator
Stadtmauer, Edward A
Vogl, Dan T
Weiss, Brendan
Binder-Scholl, Gwendolyn K
Smethurst, Dominic P
Finklestein, Jeffrey
Kulikovskaya, Irina
Gupta, Minnal
Brewer, Joanna E
Bennett, Alan D
Gerry, Andrew B
Pumphrey, Nick J
Tayton-Martin, Helen K
Ribeiro, Lilliam
Badros, Ashraf Z
Yanovich, Saul
Akpek, Gorgun
Kerr, Naseem
Philip, Sunita
Westphal, Sandra
Bruce, Levine L
Jakobsen, Bent K
June, Carl H
Kalos, Michael
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3990335
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3990335
Other Identifiers
ISSN
2051-1426
E-ISSN
2051-1426
DOI
10.1186/2051-1426-1-S1-P30
