Broad specificity profiling of TALENs results in engineered nucleases with improved DNA-cleavage spe...
Broad specificity profiling of TALENs results in engineered nucleases with improved DNA-cleavage specificity
About this item
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Author / Creator
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
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Publisher
New York: Nature Publishing Group US
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Scope and Contents
Contents
High-throughput
in vitro
analysis of TALE nuclease (TALEN) cleavage specificity gives insight into the mechanism of TALE binding and allows the design of TALENs with lower off-target activity.
Although transcription activator–like effector nucleases (TALENs) can be designed to cleave chosen DNA sequences, TALENs have activity against relat...
Alternative Titles
Full title
Broad specificity profiling of TALENs results in engineered nucleases with improved DNA-cleavage specificity
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4010127
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4010127
Other Identifiers
ISSN
1548-7091
E-ISSN
1548-7105
DOI
10.1038/nmeth.2845
