Transcription factor IRF5 drives P2X4R+-reactive microglia gating neuropathic pain
Transcription factor IRF5 drives P2X4R+-reactive microglia gating neuropathic pain
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
In response to neuronal injury or disease, microglia adopt distinct reactive phenotypes via the expression of different sets of genes. Spinal microglia expressing the purinergic P2X4 receptor (P2X4R) after peripheral nerve injury (PNI) are implicated in neuropathic pain. Here we show that interferon regulatory factor-5 (IRF5), which is induced in s...
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Full title
Transcription factor IRF5 drives P2X4R+-reactive microglia gating neuropathic pain
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4024744
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4024744
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/ncomms4771
