A high-coverage shRNA screen identifies TMEM129 as an E3 ligase involved in ER-associated protein de...
A high-coverage shRNA screen identifies TMEM129 as an E3 ligase involved in ER-associated protein degradation
About this item
Full title
Author / Creator
van de Weijer, Michael L. , Bassik, Michael C. , Luteijn, Rutger D. , Voorburg, Cornelia M. , Lohuis, Mirjam A.M. , Kremmer, Elisabeth , Hoeben, Rob C. , LeProust, Emily M. , Chen, Siyuan , Hoelen, Hanneke , Ressing, Maaike E. , Patena, Weronika , Weissman, Jonathan S. , McManus, Michael T. , Wiertz, Emmanuel J.H.J. and Lebbink, Robert Jan
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Misfolded ER proteins are retrotranslocated into the cytosol for degradation via the ubiquitin–proteasome system. The human cytomegalovirus protein US11 exploits this ER-associated protein degradation (ERAD) pathway to downregulate HLA class I molecules in virus-infected cells, thereby evading elimination by cytotoxic T-lymphocytes. US11-mediated d...
Alternative Titles
Full title
A high-coverage shRNA screen identifies TMEM129 as an E3 ligase involved in ER-associated protein degradation
Authors, Artists and Contributors
Author / Creator
Bassik, Michael C.
Luteijn, Rutger D.
Voorburg, Cornelia M.
Lohuis, Mirjam A.M.
Kremmer, Elisabeth
Hoeben, Rob C.
LeProust, Emily M.
Chen, Siyuan
Hoelen, Hanneke
Ressing, Maaike E.
Patena, Weronika
Weissman, Jonathan S.
McManus, Michael T.
Wiertz, Emmanuel J.H.J.
Lebbink, Robert Jan
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4024746
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4024746
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/ncomms4832
