GATA1s induces hyperproliferation of eosinophil precursors in Down syndrome transient leukemia
GATA1s induces hyperproliferation of eosinophil precursors in Down syndrome transient leukemia
About this item
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Author / Creator
Maroz, A , Stachorski, L , Emmrich, S , Reinhardt, K , Xu, J , Shao, Z , Käbler, S , Dertmann, T , Hitzler, J , Roberts, I , Vyas, P , Juban, G , Hennig, C , Hansen, G , Li, Z , Orkin, S , Reinhardt, D and Klusmann, J-H
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
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More information
Scope and Contents
Contents
Transient leukemia (TL) is evident in 5–10% of all neonates with Down syndrome (DS) and associated with N-terminal truncating
GATA1
mutations (GATA1s). Here we report that TL-cell clones generate abundant eosinophils in a substantial fraction of patients. Sorted eosinophils from patients with TL and eosinophilia carried the same
GATA1s
...
Alternative Titles
Full title
GATA1s induces hyperproliferation of eosinophil precursors in Down syndrome transient leukemia
Authors, Artists and Contributors
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Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4047213
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4047213
Other Identifiers
ISSN
0887-6924
E-ISSN
1476-5551
DOI
10.1038/leu.2013.373
