Senescence induced by RECQL4 dysfunction contributes to Rothmund–Thomson syndrome features in mice
Senescence induced by RECQL4 dysfunction contributes to Rothmund–Thomson syndrome features in mice
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Author / Creator
Lu, H , Fang, E F , Sykora, P , Kulikowicz, T , Zhang, Y , Becker, K G , Croteau, D L and Bohr, V A
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Cellular senescence refers to irreversible growth arrest of primary eukaryotic cells, a process thought to contribute to aging-related degeneration and disease. Deficiency of RecQ helicase RECQL4 leads to Rothmund–Thomson syndrome (RTS), and we have investigated whether senescence is involved using cellular approaches and a mouse model. We first sy...
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Full title
Senescence induced by RECQL4 dysfunction contributes to Rothmund–Thomson syndrome features in mice
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4047874
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4047874
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ISSN
2041-4889
E-ISSN
2041-4889
DOI
10.1038/cddis.2014.168
