Hippo/YAP-mediated rigidity-dependent motor neuron differentiation of human pluripotent stem cells
Hippo/YAP-mediated rigidity-dependent motor neuron differentiation of human pluripotent stem cells
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Although human pluripotent stem cells (hPSCs) can be used to regenerate neural tissues, inefficient protocols and poorly defined culture conditions have hindered their use. It is now shown that soft, micropatterned culture substrates can induce hPSCs to differentiate into motor neurons with significantly improved yields and purity in comparison to...
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Full title
Hippo/YAP-mediated rigidity-dependent motor neuron differentiation of human pluripotent stem cells
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4051885
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4051885
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ISSN
1476-1122
E-ISSN
1476-4660
DOI
10.1038/nmat3945
