MacroH2A histone variants act as a barrier upon reprogramming towards pluripotency
MacroH2A histone variants act as a barrier upon reprogramming towards pluripotency
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
The chromatin template imposes an epigenetic barrier during the process of somatic cell reprogramming. Using fibroblasts derived from macroH2A double knockout (dKO) mice, here we show that these histone variants act cooperatively as a barrier to induced pluripotency. Through manipulation of macroH2A isoforms, we further demonstrate that macroH2A2 i...
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MacroH2A histone variants act as a barrier upon reprogramming towards pluripotency
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4055026
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4055026
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/ncomms2582
