Neural stem cells genetically-modified to express neprilysin reduce pathology in Alzheimer transgeni...
Neural stem cells genetically-modified to express neprilysin reduce pathology in Alzheimer transgenic models
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Publisher
England: BioMed Central Ltd
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Language
English
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Publisher
England: BioMed Central Ltd
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Scope and Contents
Contents
Short-term neural stem cell (NSC) transplantation improves cognition in Alzheimer's disease (AD) transgenic mice by enhancing endogenous synaptic connectivity. However, this approach has no effect on the underlying beta-amyloid (Aβ) and neurofibrillary tangle pathology. Long term efficacy of cell based approaches may therefore require combinatorial...
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Full title
Neural stem cells genetically-modified to express neprilysin reduce pathology in Alzheimer transgenic models
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4055090
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4055090
Other Identifiers
ISSN
1757-6512
E-ISSN
1757-6512
DOI
10.1186/scrt440
