Excision of viral reprogramming cassettes by Cre protein transduction enables rapid, robust and effi...
Excision of viral reprogramming cassettes by Cre protein transduction enables rapid, robust and efficient derivation of transgene-free human induced pluripotent stem cells
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Publisher
England: BioMed Central Ltd
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English
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England: BioMed Central Ltd
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Contents
Integrating viruses represent robust tools for cellular reprogramming; however, the presence of viral transgenes in induced pluripotent stem cells (iPSCs) is deleterious because it holds the risk of insertional mutagenesis leading to malignant transformation. Here, we combine the robustness of lentiviral reprogramming with the efficacy of Cre recom...
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Full title
Excision of viral reprogramming cassettes by Cre protein transduction enables rapid, robust and efficient derivation of transgene-free human induced pluripotent stem cells
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4055111
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4055111
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ISSN
1757-6512
E-ISSN
1757-6512
DOI
10.1186/scrt435
