Shear stress-induced mechanotransduction protein deregulation and vasculopathy in a mouse model of p...
Shear stress-induced mechanotransduction protein deregulation and vasculopathy in a mouse model of progeria
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Publisher
England: BioMed Central Ltd
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Language
English
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England: BioMed Central Ltd
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A mouse model of progeria derived by insertion of the human mutant LMNA gene (mLMNA), producing mutant lamin A, shows loss of smooth muscle cells in the media of the ascending aorta. We hypothesized that high shear stress, in the presence of mutant lamin A, induces this vasculopathy and tried to define the molecular and cellular basis for aortic va...
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Full title
Shear stress-induced mechanotransduction protein deregulation and vasculopathy in a mouse model of progeria
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4055145
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4055145
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ISSN
1757-6512
E-ISSN
1757-6512
DOI
10.1186/scrt429
