Articular cartilage chondrocytes express aromatase and use enzymes involved in estrogen metabolism
Articular cartilage chondrocytes express aromatase and use enzymes involved in estrogen metabolism
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Publisher
England: BioMed Central Ltd
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Language
English
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Publisher
England: BioMed Central Ltd
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Contents
Sex hormones, especially estrogens, have been implicated in articular cartilage metabolism and the pathogenesis of postmenopausal osteoarthritis. The conversion by aromatase (CYP19A1) of androstenedione into estrone (E1) and of testosterone into 17β-estradiol (E2) plays a key role in the endogenous synthesis of estrogens in tissue.
We analyzed t...
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Full title
Articular cartilage chondrocytes express aromatase and use enzymes involved in estrogen metabolism
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4060203
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4060203
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ISSN
1478-6354
E-ISSN
1478-6362,1478-6354
DOI
10.1186/ar4539
