Isolation of single-base genome-edited human iPS cells without antibiotic selection
Isolation of single-base genome-edited human iPS cells without antibiotic selection
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New York: Nature Publishing Group US
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English
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New York: Nature Publishing Group US
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This paper describes a method based on sib-selection to isolate rare human pluripotent stem cell clones with a precise engineered mutation.
Precise editing of human genomes in pluripotent stem cells by homology-driven repair of targeted nuclease–induced cleavage has been hindered by the difficulty of isolating rare clones. We developed an effici...
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Full title
Isolation of single-base genome-edited human iPS cells without antibiotic selection
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4063274
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4063274
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ISSN
1548-7091
E-ISSN
1548-7105
DOI
10.1038/nmeth.2840
