Myosin Vb uncoupling from RAB8A and RAB11A elicits microvillus inclusion disease
Myosin Vb uncoupling from RAB8A and RAB11A elicits microvillus inclusion disease
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Publisher
United States: American Society for Clinical Investigation
Journal title
Language
English
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Publisher
United States: American Society for Clinical Investigation
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Contents
Microvillus inclusion disease (MVID) is a severe form of congenital diarrhea that arises from inactivating mutations in the gene encoding myosin Vb (MYO5B). We have examined the association of mutations in MYO5B and disruption of microvillar assembly and polarity in enterocytes. Stable MYO5B knockdown (MYO5B-KD) in CaCo2-BBE cells elicited loss of...
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Full title
Myosin Vb uncoupling from RAB8A and RAB11A elicits microvillus inclusion disease
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4071383
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4071383
Other Identifiers
ISSN
0021-9738
E-ISSN
1558-8238
DOI
10.1172/JCI71651
