Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase
Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase
About this item
Full title
Author / Creator
Madiraju, Anila K. , Erion, Derek M. , Rahimi, Yasmeen , Zhang, Xian-Man , Braddock, Demetrios T. , Albright, Ronald A. , Prigaro, Brett J. , Wood, John L. , Bhanot, Sanjay , MacDonald, Michael J. , Jurczak, Michael J. , Camporez, Joao-Paulo , Lee, Hui-Young , Cline, Gary W. , Samuel, Varman T. , Kibbey, Richard G. and Shulman, Gerald I.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Metformin treatment of rats at physiologically relevant doses inhibits the redox shuttle enzyme mitochondrial glycerophosphate dehydrogenase.
Molecular mechanism of metformin
Metformin, possibly the most widely prescribed antidiabetic in the world, specifically reduces hepatic gluconeogenesis without increasing insulin secretion, inducing wei...
Alternative Titles
Full title
Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase
Authors, Artists and Contributors
Author / Creator
Erion, Derek M.
Rahimi, Yasmeen
Zhang, Xian-Man
Braddock, Demetrios T.
Albright, Ronald A.
Prigaro, Brett J.
Wood, John L.
Bhanot, Sanjay
MacDonald, Michael J.
Jurczak, Michael J.
Camporez, Joao-Paulo
Lee, Hui-Young
Cline, Gary W.
Samuel, Varman T.
Kibbey, Richard G.
Shulman, Gerald I.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4074244
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4074244
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/nature13270
