Decreased RORC-dependent silencing of prostaglandin receptor EP2 induces autoimmune Th17 cells
Decreased RORC-dependent silencing of prostaglandin receptor EP2 induces autoimmune Th17 cells
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Publisher
United States: American Society for Clinical Investigation
Journal title
Language
English
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Publisher
United States: American Society for Clinical Investigation
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Contents
Prostaglandin E2 (PGE2) promotes Th17 expansion while otherwise inhibiting other CD4+ T cell subsets. Here, we identified a PGE2-dependent pathway that induces pathogenic Th17 cells in autoimmune disease and is regulated by the transcription factor RORC. Compared with other CD4+ cell types from healthy subjects, there is a surprising lack of the pr...
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Full title
Decreased RORC-dependent silencing of prostaglandin receptor EP2 induces autoimmune Th17 cells
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4089462
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4089462
Other Identifiers
ISSN
0021-9738
E-ISSN
1558-8238
DOI
10.1172/JCI72973
