Cooperation of breast cancer proteins PALB2 and piccolo BRCA2 in stimulating homologous recombinatio...
Cooperation of breast cancer proteins PALB2 and piccolo BRCA2 in stimulating homologous recombination
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Publisher
New York: Nature Publishing Group US
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Language
English
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New York: Nature Publishing Group US
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Contents
Tumor suppressor PALB2 is known to interact with BRCA2 and promote homologous recombination
in vivo
. Now PALB2's activities have been studied, together with a BRCA2 chimeric protein, revealing that PALB2 binds D-loop structures, interacts directly with RAD51 and promotes strand invasion synergistically with BRCA2.
Inherited mutations in h...
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Full title
Cooperation of breast cancer proteins PALB2 and piccolo BRCA2 in stimulating homologous recombination
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4094107
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4094107
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ISSN
1545-9993
E-ISSN
1545-9985
DOI
10.1038/nsmb.1915
