Mechanisms of Proton Conduction and Gating in Influenza M2 Proton Channels from Solid-State NMR
Mechanisms of Proton Conduction and Gating in Influenza M2 Proton Channels from Solid-State NMR
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Author / Creator
Hu, Fanghao , Luo, Wenbin and Hong, Mei
Publisher
Washington, DC: American Association for the Advancement of Science
Journal title
Language
English
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Publication information
Publisher
Washington, DC: American Association for the Advancement of Science
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Contents
The M2 protein of influenza viruses forms an acid-activated tetrameric proton channel. We used solid-state nuclear magnetic resonance spectroscopy to determine the structure and functional dynamics of the pH-sensing and proton-selective histidine-37 in M2 bound to a cholesterol-containing virus-envelope-mimetic membrane so as to better understand t...
Alternative Titles
Full title
Mechanisms of Proton Conduction and Gating in Influenza M2 Proton Channels from Solid-State NMR
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4102303
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4102303
Other Identifiers
ISSN
0036-8075
E-ISSN
1095-9203
DOI
10.1126/science.1191714
