Molecular determinants of Hv1 proton channel inhibition by guanidine derivatives
Molecular determinants of Hv1 proton channel inhibition by guanidine derivatives
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United States: National Academy of Sciences
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English
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United States: National Academy of Sciences
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The voltage-gated proton channel Hv1 plays important roles in proton extrusion, pH homeostasis, and production of reactive oxygen species in a variety of cell types. Excessive Hv1 activity increases proliferation and invasiveness in cancer cells and worsens brain damage in ischemic stroke. The channel is composed of two subunits, each containing a...
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Molecular determinants of Hv1 proton channel inhibition by guanidine derivatives
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4103315
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4103315
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1324012111