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Molecular determinants of Hv1 proton channel inhibition by guanidine derivatives

Molecular determinants of Hv1 proton channel inhibition by guanidine derivatives

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4103315

Molecular determinants of Hv1 proton channel inhibition by guanidine derivatives

About this item

Full title

Molecular determinants of Hv1 proton channel inhibition by guanidine derivatives

Publisher

United States: National Academy of Sciences

Journal title

Proceedings of the National Academy of Sciences - PNAS, 2014-07, Vol.111 (27), p.9971-9976

Language

English

Formats

Publication information

Publisher

United States: National Academy of Sciences

More information

Scope and Contents

Contents

The voltage-gated proton channel Hv1 plays important roles in proton extrusion, pH homeostasis, and production of reactive oxygen species in a variety of cell types. Excessive Hv1 activity increases proliferation and invasiveness in cancer cells and worsens brain damage in ischemic stroke. The channel is composed of two subunits, each containing a...

Alternative Titles

Full title

Molecular determinants of Hv1 proton channel inhibition by guanidine derivatives

Authors, Artists and Contributors

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4103315

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4103315

Other Identifiers

ISSN

0027-8424

E-ISSN

1091-6490

DOI

10.1073/pnas.1324012111

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