Design of a colicin E7 based chimeric zinc-finger nuclease
Design of a colicin E7 based chimeric zinc-finger nuclease
About this item
Full title
Author / Creator
Publisher
Cham: Springer International Publishing
Journal title
Language
English
Formats
Publication information
Publisher
Cham: Springer International Publishing
Subjects
More information
Scope and Contents
Contents
Colicin E7 is a natural bacterial toxin. Its nuclease domain (NColE7) enters the target cell and kills it by digesting the nucleic acids. The HNH-motif as the catalytic centre of NColE7 at the C-terminus requires the positively charged N-terminal loop for the nuclease activity—offering opportunities for allosteric control in a NColE7-based artifici...
Alternative Titles
Full title
Design of a colicin E7 based chimeric zinc-finger nuclease
Authors, Artists and Contributors
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4104000
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4104000
Other Identifiers
ISSN
0920-654X,1573-4951
E-ISSN
1573-4951
DOI
10.1007/s10822-014-9765-8
