Genomic profiling in Down syndrome acute lymphoblastic leukemia identifies histone gene deletions as...
Genomic profiling in Down syndrome acute lymphoblastic leukemia identifies histone gene deletions associated with altered methylation profiles
About this item
Full title
Author / Creator
Loudin, M G , Wang, J , Eastwood Leung, H-C , Gurusiddappa, S , Meyer, J , Condos, G , Morrison, D , Tsimelzon, A , Devidas, M , Heerema, N A , Carroll, A J , Plon, S E , Hunger, S P , Basso, G , Pession, A , Bhojwani, D , Carroll, W L and Rabin, K R
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Patients with Down syndrome (DS) and acute lymphoblastic leukemia (ALL) have distinct clinical and biological features. Whereas most DS-ALL cases lack the sentinel cytogenetic lesions that guide risk assignment in childhood ALL,
JAK2
mutations and
CRLF2
overexpression are highly enriched. To further characterize the unique biology of DS...
Alternative Titles
Full title
Genomic profiling in Down syndrome acute lymphoblastic leukemia identifies histone gene deletions associated with altered methylation profiles
Authors, Artists and Contributors
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4107887
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4107887
Other Identifiers
ISSN
0887-6924
E-ISSN
1476-5551
DOI
10.1038/leu.2011.128
