Protein painting reveals solvent-excluded drug targets hidden within native protein–protein interfac...
Protein painting reveals solvent-excluded drug targets hidden within native protein–protein interfaces
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Identifying the contact regions between a protein and its binding partners is essential for creating therapies that block the interaction. Unfortunately, such contact regions are extremely difficult to characterize because they are hidden inside the binding interface. Here we introduce protein painting as a new tool that employs small molecules as...
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Full title
Protein painting reveals solvent-excluded drug targets hidden within native protein–protein interfaces
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4109009
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4109009
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/ncomms5413
