TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-β
TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-β
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New York: Nature Publishing Group US
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Language
English
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New York: Nature Publishing Group US
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Contents
Toll-like receptor 4 (TLR4) induces two distinct signaling pathways controlled by the TIRAP-MyD88 and TRAM-TRIF pairs of adaptor proteins, which elicit the production of proinflammatory cytokines and type I interferons, respectively. How TLR4 coordinates the activation of these two pathways is unknown. Here we show that TLR4 activated these two sig...
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Full title
TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-β
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4112825
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4112825
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ISSN
1529-2908
E-ISSN
1529-2916
DOI
10.1038/ni1569
