A Cancer-specific Monoclonal Antibody Recognizes the Aberrantly Glycosylated Podoplanin
A Cancer-specific Monoclonal Antibody Recognizes the Aberrantly Glycosylated Podoplanin
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Podoplanin (PDPN/Aggrus/T1α), a platelet aggregation-inducing mucin-like sialoglycoprotein, is highly expressed in many cancers and normal tissues. A neutralizing monoclonal antibody (mAb; NZ-1) can block the association between podoplanin and C-type lectin-like receptor-2 (CLEC-2) and inhibit podoplanin-induced cancer metastasis, but NZ-1 reacts w...
Alternative Titles
Full title
A Cancer-specific Monoclonal Antibody Recognizes the Aberrantly Glycosylated Podoplanin
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4118152
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4118152
Other Identifiers
ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/srep05924
