Response and resistance to MEK inhibition in leukaemias initiated by hyperactive Ras
Response and resistance to MEK inhibition in leukaemias initiated by hyperactive Ras
About this item
Full title
Author / Creator
Lauchle, Jennifer O. , Kim, Doris , Le, Doan T. , Akagi, Keiko , Crone, Michael , Krisman, Kimberly , Warner, Kegan , Bonifas, Jeannette M. , Li, Qing , Coakley, Kristen M. , Diaz-Flores, Ernesto , Gorman, Matthew , Przybranowski, Sally , Tran, Mary , Kogan, Scott C. , Roose, Jeroen P. , Copeland, Neal G. , Jenkins, Nancy A. , Parada, Luis , Wolff, Linda , Sebolt-Leopold, Judith and Shannon, Kevin
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
MEK inhibitor resistance linked to Ras
In a mouse model for myeloproliferative disorder (MPD) driven by loss of NF-1 (which activates the Ras–MEK–MAPK pathway), additional mutations were created by insertional mutagenesis that led to progression of the disease to acute myeloid leukaemias (AMLs). Interestingly, MEK inhibitors are not effective in...
Alternative Titles
Full title
Response and resistance to MEK inhibition in leukaemias initiated by hyperactive Ras
Authors, Artists and Contributors
Author / Creator
Kim, Doris
Le, Doan T.
Akagi, Keiko
Crone, Michael
Krisman, Kimberly
Warner, Kegan
Bonifas, Jeannette M.
Li, Qing
Coakley, Kristen M.
Diaz-Flores, Ernesto
Gorman, Matthew
Przybranowski, Sally
Tran, Mary
Kogan, Scott C.
Roose, Jeroen P.
Copeland, Neal G.
Jenkins, Nancy A.
Parada, Luis
Wolff, Linda
Sebolt-Leopold, Judith
Shannon, Kevin
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4119783
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4119783
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/nature08279
