Unnatural amino acids increase sensitivity and provide for the design of highly selective caspase su...
Unnatural amino acids increase sensitivity and provide for the design of highly selective caspase substrates
About this item
Full title
Author / Creator
Poreba, M , Kasperkiewicz, P , Snipas, S J , Fasci, D , Salvesen, G S and Drag, M
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Traditional combinatorial peptidyl substrate library approaches generally utilize natural amino acids, limiting the usefulness of this tool in generating selective substrates for proteases that share similar substrate specificity profiles. To address this limitation, we synthesized a Hybrid Combinatorial Substrate Library (HyCoSuL) with the general...
Alternative Titles
Full title
Unnatural amino acids increase sensitivity and provide for the design of highly selective caspase substrates
Authors, Artists and Contributors
Author / Creator
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4131180
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4131180
Other Identifiers
ISSN
1350-9047
E-ISSN
1476-5403
DOI
10.1038/cdd.2014.64
