A new mechanism of allostery in a G protein–coupled receptor dimer
A new mechanism of allostery in a G protein–coupled receptor dimer
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Full title
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Publisher
New York: Nature Publishing Group US
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Language
English
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Publisher
New York: Nature Publishing Group US
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Contents
A compound previously identified as a dopamine D2 receptor allosteric modulator was found to be a bitopic ligand that binds the orthosteric and allosteric sites to allow binding to one D2 protomer and allosteric modulation of the associated protomer.
SB269652 is to our knowledge the first drug-like allosteric modulator of the dopamine D
2
...
Alternative Titles
Full title
A new mechanism of allostery in a G protein–coupled receptor dimer
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4138267
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4138267
Other Identifiers
ISSN
1552-4450
E-ISSN
1552-4469
DOI
10.1038/nchembio.1593
