Endosomal GPCR signaling turned off by negative feedback actions of PKA and v-ATPase
Endosomal GPCR signaling turned off by negative feedback actions of PKA and v-ATPase
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New York: Nature Publishing Group US
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English
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New York: Nature Publishing Group US
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A GPCR, the parathyroid hormone receptor, can elicit a sustained signal from internal membranes after internalization. The signal was found to be terminated by a feedback mechanism where PKA activates the proton pump v-ATPase, which acidifies endosomes.
The PTH receptor is to our knowledge one of the first G protein–coupled receptor (GPCR) found...
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Endosomal GPCR signaling turned off by negative feedback actions of PKA and v-ATPase
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4138287
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4138287
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ISSN
1552-4450
E-ISSN
1552-4469
DOI
10.1038/nchembio.1589
