Dimerization of HIV-1 protease occurs through two steps relating to the mechanism of protease dimeri...
Dimerization of HIV-1 protease occurs through two steps relating to the mechanism of protease dimerization inhibition by darunavir
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United States: National Academy of Sciences
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Language
English
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Publisher
United States: National Academy of Sciences
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Contents
Dimerization of HIV-1 protease (PR) subunits is an essential process for PR’s acquisition of proteolytic activity, which plays a critical role in the maturation of HIV-1. Recombinant wild-type PR (PR ᵂᵀ) proved to dimerize, as examined with electrospray ionization mass spectrometry; however, two active site interface PR mutants (PR ᵀ²⁶ᴬ and PR ᴿ⁸⁷ᴷ...
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Full title
Dimerization of HIV-1 protease occurs through two steps relating to the mechanism of protease dimerization inhibition by darunavir
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4142999
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4142999
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1400027111
