Selective suppression of excessive GluN2C expression rescues early epilepsy in a tuberous sclerosis...
Selective suppression of excessive GluN2C expression rescues early epilepsy in a tuberous sclerosis murine model
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Author / Creator
Lozovaya, N. , Gataullina, S. , Tsintsadze, T. , Tsintsadze, V. , Pallesi-Pocachard, E. , Minlebaev, M. , Goriounova, N. A. , Buhler, E. , Watrin, F. , Shityakov, S. , Becker, A. J. , Bordey, A. , Milh, M. , Scavarda, D. , Bulteau, C. , Dorfmuller, G. , Delalande, O. , Represa, A. , Cardoso, C. , Dulac, O. , Ben-Ari, Y. and Burnashev, N.
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Tuberous sclerosis complex (TSC), caused by dominant mutations in either
TSC1
or
TSC2
tumour suppressor genes is characterized by the presence of brain malformations, the cortical tubers that are thought to contribute to the generation of pharmacoresistant epilepsy. Here we report that tuberless heterozygote
Tsc1
+/−
mice show...
Alternative Titles
Full title
Selective suppression of excessive GluN2C expression rescues early epilepsy in a tuberous sclerosis murine model
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4143949
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4143949
Other Identifiers
E-ISSN
2041-1723
DOI
10.1038/ncomms5563
