Large hypomethylated blocks as a universal defining epigenetic alteration in human solid tumors
Large hypomethylated blocks as a universal defining epigenetic alteration in human solid tumors
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Publisher
England: BioMed Central Ltd
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Language
English
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England: BioMed Central Ltd
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Contents
One of the most provocative recent observations in cancer epigenetics is the discovery of large hypomethylated blocks, including single copy genes, in colorectal cancer, that correspond in location to heterochromatic LOCKs (large organized chromatin lysine-modifications) and LADs (lamin-associated domains).
Here we performed a comprehensive geno...
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Full title
Large hypomethylated blocks as a universal defining epigenetic alteration in human solid tumors
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4154522
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4154522
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ISSN
1756-994X
E-ISSN
1756-994X
DOI
10.1186/s13073-014-0061-y
