Tip-link protein protocadherin 15 interacts with transmembrane channel-like proteins TMC1 and TMC2
Tip-link protein protocadherin 15 interacts with transmembrane channel-like proteins TMC1 and TMC2
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Publisher
United States: National Academy of Sciences
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Language
English
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Publisher
United States: National Academy of Sciences
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Contents
The tip link protein protocadherin 15 (PCDH15) is a central component of the mechanotransduction complex in auditory and vestibular hair cells. PCDH15 is hypothesized to relay external forces to the mechanically gated channel located near its cytoplasmic C terminus. How PCDH15 is coupled to the transduction machinery is not clear. Using a membrane-...
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Full title
Tip-link protein protocadherin 15 interacts with transmembrane channel-like proteins TMC1 and TMC2
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4156717
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4156717
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1402152111
