Breast-Cancer Risk in Families with Mutations in PALB2
Breast-Cancer Risk in Families with Mutations in PALB2
About this item
Full title
Author / Creator
Antoniou, Antonis C , Casadei, Silvia , Heikkinen, Tuomas , Barrowdale, Daniel , Pylkäs, Katri , Roberts, Jonathan , Lee, Andrew , Subramanian, Deepak , De Leeneer, Kim , Fostira, Florentia , Tomiak, Eva , Neuhausen, Susan L , Teo, Zhi L , Khan, Sofia , Aittomäki, Kristiina , Moilanen, Jukka S , Turnbull, Clare , Seal, Sheila , Mannermaa, Arto , Kallioniemi, Anne , Lindeman, Geoffrey J , Buys, Saundra S , Andrulis, Irene L , Radice, Paolo , Tondini, Carlo , Manoukian, Siranoush , Toland, Amanda E , Miron, Penelope , Weitzel, Jeffrey N , Domchek, Susan M , Poppe, Bruce , Claes, Kathleen B.M , Yannoukakos, Drakoulis , Concannon, Patrick , Bernstein, Jonine L , James, Paul A , Easton, Douglas F , Goldgar, David E , Hopper, John L , Rahman, Nazneen , Peterlongo, Paolo , Nevanlinna, Heli , King, Mary-Claire , Couch, Fergus J , Southey, Melissa C , Winqvist, Robert , Foulkes, William D and Tischkowitz, Marc
Publisher
Waltham, MA: Massachusetts Medical Society
Journal title
Language
English
Formats
Publication information
Publisher
Waltham, MA: Massachusetts Medical Society
Subjects
More information
Scope and Contents
Contents
A multinational study of 154 families with
PALB2
mutations shows that mutation carriers have a 14% risk of breast cancer by 50 years of age and a 35% risk by 70 years of age, which is similar to the risk associated with
BRCA2
mutations.
PALB2 (partner and localizer of BRCA2) was originally identified as a BRCA2-interacting protein th...
Alternative Titles
Full title
Breast-Cancer Risk in Families with Mutations in PALB2
Authors, Artists and Contributors
Author / Creator
Casadei, Silvia
Heikkinen, Tuomas
Barrowdale, Daniel
Pylkäs, Katri
Roberts, Jonathan
Lee, Andrew
Subramanian, Deepak
De Leeneer, Kim
Fostira, Florentia
Tomiak, Eva
Neuhausen, Susan L
Teo, Zhi L
Khan, Sofia
Aittomäki, Kristiina
Moilanen, Jukka S
Turnbull, Clare
Seal, Sheila
Mannermaa, Arto
Kallioniemi, Anne
Lindeman, Geoffrey J
Buys, Saundra S
Andrulis, Irene L
Radice, Paolo
Tondini, Carlo
Manoukian, Siranoush
Toland, Amanda E
Miron, Penelope
Weitzel, Jeffrey N
Domchek, Susan M
Poppe, Bruce
Claes, Kathleen B.M
Yannoukakos, Drakoulis
Concannon, Patrick
Bernstein, Jonine L
James, Paul A
Easton, Douglas F
Goldgar, David E
Hopper, John L
Rahman, Nazneen
Peterlongo, Paolo
Nevanlinna, Heli
King, Mary-Claire
Couch, Fergus J
Southey, Melissa C
Winqvist, Robert
Foulkes, William D
Tischkowitz, Marc
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4157599
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4157599
Other Identifiers
ISSN
0028-4793
E-ISSN
1533-4406
DOI
10.1056/NEJMoa1400382
