Rapid mobilization of hematopoietic progenitors by AMD3100 and catecholamines is mediated by CXCR4-d...
Rapid mobilization of hematopoietic progenitors by AMD3100 and catecholamines is mediated by CXCR4-dependent SDF-1 release from bone marrow stromal cells
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Author / Creator
Dar, A , Schajnovitz, A , Lapid, K , Kalinkovich, A , Itkin, T , Ludin, A , Kao, W-M , Battista, M , Tesio, M , Kollet, O , Cohen, N N , Margalit, R , Buss, E C , Baleux, F , Oishi, S , Fujii, N , Larochelle, A , Dunbar, C E , Broxmeyer, H E , Frenette, P S and Lapidot, T
Publisher
London: Nature Publishing Group UK
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English
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Publisher
London: Nature Publishing Group UK
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Contents
Steady-state egress of hematopoietic progenitor cells can be rapidly amplified by mobilizing agents such as AMD3100, the mechanism, however, is poorly understood. We report that AMD3100 increased the homeostatic release of the chemokine stromal cell derived factor-1 (SDF-1) to the circulation in mice and non-human primates. Neutralizing antibodies...
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Full title
Rapid mobilization of hematopoietic progenitors by AMD3100 and catecholamines is mediated by CXCR4-dependent SDF-1 release from bone marrow stromal cells
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4175714
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4175714
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ISSN
0887-6924
E-ISSN
1476-5551
DOI
10.1038/leu.2011.62
