A Novel I221L Substitution in Neuraminidase Confers High-Level Resistance to Oseltamivir in Influenz...
A Novel I221L Substitution in Neuraminidase Confers High-Level Resistance to Oseltamivir in Influenza B Viruses
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Author / Creator
Escuret, Vanessa , Collins, Patrick J. , Casalegno, Jean-Sébastien , Vachieri, Sebastien G. , Cattle, Nicholas , Ferraris, Olivier , Sabatier, Murielle , Frobert, Emilie , Caro, Valérie , Skehel, John J. , Gamblin, Steve , Valla, Frédéric , Valette, Martine , Ottmann, Michèle , McCauley, John W. , Daniels, Rodney S. and Lina, Bruno
Publisher
United States: Oxford University Press
Journal title
Language
English
Formats
Publication information
Publisher
United States: Oxford University Press
Subjects
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Scope and Contents
Contents
Influenza B viruses with a novel I221L substitution in neuraminidase (NA) conferring high-level resistance to oseltamivir were isolated from an immunocompromised patient after prolonged oseltamivir treatment. Methods. Enzymatic characterization of the NAs (Km, Ki) and the in vitro fitness of viruses carrying wild-type or mutated (I221L) NA genes we...
Alternative Titles
Full title
A Novel I221L Substitution in Neuraminidase Confers High-Level Resistance to Oseltamivir in Influenza B Viruses
Authors, Artists and Contributors
Author / Creator
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Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4176448
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4176448
Other Identifiers
ISSN
0022-1899
E-ISSN
1537-6613
DOI
10.1093/infdis/jiu244
