Whole-genome haplotype reconstruction using proximity-ligation and shotgun sequencing
Whole-genome haplotype reconstruction using proximity-ligation and shotgun sequencing
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Genetic variants are grouped into chromosome-spanning haplotypes with the help of chromatin-interaction data.
Rapid advances in high-throughput sequencing facilitate variant discovery and genotyping, but linking variants into a single haplotype remains challenging. Here we demonstrate HaploSeq, an approach for assembling chromosome-scale haploty...
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Whole-genome haplotype reconstruction using proximity-ligation and shotgun sequencing
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4180835
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4180835
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ISSN
1087-0156,1546-1696
E-ISSN
1546-1696
DOI
10.1038/nbt.2728
