Antibodies to PfSEA-1 block parasite egress from RBCs and protect against malaria infection
Antibodies to PfSEA-1 block parasite egress from RBCs and protect against malaria infection
About this item
Full title
Author / Creator
Raj, Dipak K. , Nixon, Christian P. , Nixon, Christina E. , Dvorin, Jeffrey D. , DiPetrillo, Christen G. , Pond-Tor, Sunthorn , Wu, Hai-Wei , Jolly, Grant , Pischel, Lauren , Lu, Ailin , Michelow, Ian C. , Cheng, Ling , Conteh, Solomon , McDonald, Emily A. , Absalon, Sabrina , Holte, Sarah E. , Friedman, Jennifer F. , Fried, Michal , Duffy, Patrick E. and Kurtis, Jonathan D.
Publisher
United States: American Association for the Advancement of Science
Journal title
Language
English
Formats
Publication information
Publisher
United States: American Association for the Advancement of Science
Subjects
More information
Scope and Contents
Contents
Novel vaccines are urgently needed to reduce the burden of severe malaria. Using a differential whole-proteome screening method, we identified Plasmodium falciparum schizont egress antigen-1 (PfSEA-1), a 244-kilodalton parasite antigen expressed in schizont-infected red blood cells (RBCs). Antibodies to PfSEA-1 decreased parasite replication by arr...
Alternative Titles
Full title
Antibodies to PfSEA-1 block parasite egress from RBCs and protect against malaria infection
Authors, Artists and Contributors
Author / Creator
Nixon, Christian P.
Nixon, Christina E.
Dvorin, Jeffrey D.
DiPetrillo, Christen G.
Pond-Tor, Sunthorn
Wu, Hai-Wei
Jolly, Grant
Pischel, Lauren
Lu, Ailin
Michelow, Ian C.
Cheng, Ling
Conteh, Solomon
McDonald, Emily A.
Absalon, Sabrina
Holte, Sarah E.
Friedman, Jennifer F.
Fried, Michal
Duffy, Patrick E.
Kurtis, Jonathan D.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4184151
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4184151
Other Identifiers
ISSN
0036-8075
E-ISSN
1095-9203
DOI
10.1126/science.1254417
