Kainate receptor activation induces glycine receptor endocytosis through PKC deSUMOylation
Kainate receptor activation induces glycine receptor endocytosis through PKC deSUMOylation
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Author / Creator
Sun, Hao , Lu, Li , Zuo, Yong , Wang, Yan , Jiao, Yingfu , Zeng, Wei-Zheng , Huang, Chao , Zhu, Michael X. , Zamponi, Gerald W. , Zhou, Tong , Xu, Tian-Le , Cheng, Jinke and Li, Yong
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Surface expression and regulated endocytosis of glycine receptors (GlyRs) play a critical function in balancing neuronal excitability. SUMOylation (SUMO modification) is of critical importance for maintaining neuronal function in the central nervous system. Here we show that activation of kainate receptors (KARs) causes GlyR endocytosis in a calciu...
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Full title
Kainate receptor activation induces glycine receptor endocytosis through PKC deSUMOylation
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4199113
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4199113
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/ncomms5980
