Glucose substitution prolongs maintenance of energy homeostasis and lifespan of telomere dysfunction...
Glucose substitution prolongs maintenance of energy homeostasis and lifespan of telomere dysfunctional mice
About this item
Full title
Author / Creator
Missios, Pavlos , Zhou, Yuan , Guachalla, Luis Miguel , von Figura, Guido , Wegner, Andre , Chakkarappan, Sundaram Reddy , Binz, Tina , Gompf, Anne , Hartleben, Götz , Burkhalter, Martin D. , Wulff, Veronika , Günes, Cagatay , Sattler, Rui Wang , Song, Zhangfa , Illig, Thomas , Klaus, Susanne , Böhm, Bernhard O. , Wenz, Tina , Hiller, Karsten and Rudolph, K. Lenhard
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
DNA damage and telomere dysfunction shorten organismal lifespan. Here we show that oral glucose administration at advanced age increases health and lifespan of telomere dysfunctional mice. The study reveals that energy consumption increases in telomere dysfunctional cells resulting in enhanced glucose metabolism both in glycolysis and in the tricar...
Alternative Titles
Full title
Glucose substitution prolongs maintenance of energy homeostasis and lifespan of telomere dysfunctional mice
Authors, Artists and Contributors
Author / Creator
Zhou, Yuan
Guachalla, Luis Miguel
von Figura, Guido
Wegner, Andre
Chakkarappan, Sundaram Reddy
Binz, Tina
Gompf, Anne
Hartleben, Götz
Burkhalter, Martin D.
Wulff, Veronika
Günes, Cagatay
Sattler, Rui Wang
Song, Zhangfa
Illig, Thomas
Klaus, Susanne
Böhm, Bernhard O.
Wenz, Tina
Hiller, Karsten
Rudolph, K. Lenhard
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4199114
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4199114
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/ncomms5924
