Hepatocyte-specific Pten deficiency results in steatohepatitis and hepatocellular carcinomas
Hepatocyte-specific Pten deficiency results in steatohepatitis and hepatocellular carcinomas
About this item
Full title
Author / Creator
Publisher
American Society for Clinical Investigation
Journal title
Language
English
Formats
Publication information
Publisher
American Society for Clinical Investigation
More information
Scope and Contents
Contents
PTEN
is a tumor suppressor gene mutated in many human cancers, and its expression is reduced or absent in almost half of hepatoma patients. We used the Cre-
loxP
system to generate a hepatocyte-specific null mutation of
Pten
in mice (
AlbCrePten
flox/flox
mice).
AlbCrePten
flox/flox
mice showed massive hepatomegaly...
Alternative Titles
Full title
Hepatocyte-specific Pten deficiency results in steatohepatitis and hepatocellular carcinomas
Authors, Artists and Contributors
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_420505
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_420505
Other Identifiers
ISSN
0021-9738
DOI
10.1172/JCI200420513
