Inhibition of a novel fibrogenic factor Tl1a reverses established colonic fibrosis
Inhibition of a novel fibrogenic factor Tl1a reverses established colonic fibrosis
About this item
Full title
Author / Creator
Shih, D Q , Zheng, L , Zhang, X , Zhang, H , Kanazawa, Y , Ichikawa, R , Wallace, K L , Chen, J , Pothoulakis, C , Koon, H W and Targan, S R
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Nature Publishing Group US
Subjects
More information
Scope and Contents
Contents
Intestinal fibrostenosis is among the hallmarks of severe Crohn’s disease. Patients with certain
TNFSF15
(gene name for TL1A) variants over-express TL1A and have a higher risk of developing strictures in the small intestine. In addition, sustained Tl1a expression in mice leads to small and large intestinal fibrostenosis under colitogenic cond...
Alternative Titles
Full title
Inhibition of a novel fibrogenic factor Tl1a reverses established colonic fibrosis
Authors, Artists and Contributors
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Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4205266
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4205266
Other Identifiers
ISSN
1933-0219
E-ISSN
1935-3456
DOI
10.1038/mi.2014.37
